Isabelle Ruf-Weber obtained her honours diploma in wind orchestra conduction in 1989 at the Lucerne University of Music (Hochschule Luzern - Musik), obtaining on the same year a diploma in transverse flute.
She continued her studies in orchestral conduction at the University of Michigan (USA) and choir conduction in Lucerne; several master's courses abroad and a one-year postgraduate training in conduction with Johannes Schlaefli at the Zurich University of the Arts (Zürcher Hochschule der Künste).
She has conducted the most diverse orchestras, such as the FM Neuenkirch wind orchestra for 25 years, also assuming, from 2000 to 2003, the conduction of the Sursee orchestra and then that of the Malters orchestra association, from 2003 to 2007. Artistic director of the Landesblasorchester Baden-Württemberg from 2001 to 2013. Director of the Freiburg Landwehr from 2007 to 2017.
She has served as a conductor and production manager at the Sursee Municipal Theatre from 2002 to 2022.
She has collaborated with several youth bands, such as the National Youth Band and the South Tyrolean Youth Music.
Isabelle Ruf-Weber is as a guest conductor and musical educator that also collaborates on various orchestral projects across borders. She works for the training and development of juries and conductors. She has been teaching as a guest lecturer at the Bundesakademie in Trossingen, Germany since the autumn of 2006. She also taught wind orchestra conduction at the Lucerne University of Music from 2009 to 2014.
Isabelle Ruf-Weber is in great demand as a member of the jury at various music and conduction competitions organized in Switzerland and abroad.
In May 2017, she was awarded the Stephan Jaeggi Award in recognition of her commitment to the service of Swiss wind music.